研究人员发现可消灭鲍氏不动杆菌的抗生素zosurabalpin,创下科学界50多年来首见的重大突破。图为zosurabalpin结构与动物实验数值。(图撷自Nature网站)
具抗药性的鲍氏不动杆菌,经常导致院内患者感染死亡,不过,瑞士罗氏制药公司研究与开发中心的专家,发现了可以消灭这种细菌的抗生素zosurabalpin,创下科学界50多年来首见的重大突破,相关研究已于3日刊登在顶尖期刊《自然》上。
据《纽约邮报》报导,鲍氏不动杆菌属于革兰氏阴性菌,进入人体不同部位后会引起菌血症、肺炎、脑膜炎、腹膜炎、心内膜炎,也会感染泌尿道和皮肤,由于其具有抗药性,因此让医护相当头疼。
不过,专门针对鲍氏不动杆菌的抗生素zosurabalpin,可阻断脂多醣(Lipopolysaccharide,LPS)构成鲍氏不动杆菌外膜的能力,进而导致细菌死亡,在动物实验中已获得验证。
瑞士罗氏全球传染病主管布拉德利(Kenneth
Bradley)表示,这是50多年来首次发现有抗生素可以治疗革兰氏阴性菌感染,目前已著手展开第一期人体临床试验,评估zosurabalpin的安全性和耐受性等等。
布拉德利指出,发现zosurabalpin绝对是一项科学重大突破,毕竟这几十年来各种革兰氏阴性细菌的抗药性一直在上升,研究人员透过zosurabalpin的灭菌机制,未来有希望进一步研究出消灭其他抗药性细菌的抗生素。
美国纽约大学朗格尼医学中心临床医学教授西格尔(Marc
Siegel),透露这些年来在医院的最后一道防线一直都是碳青霉烯类(Carbapenem)抗生素,但相关抗药性细菌一直在增加,包括碳青霉烯类抗药性鲍氏不动杆菌(CRAB),这些菌株非常难以治疗,因此zosurabalpin的发现无疑相当重要。
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